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  The Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT) was a large, randomized, placebo-controlled trial that was conducted in two parts:The first two-year study aimed to assess whether chondroitin and/or glucosamine could alleviate the pain of knee osteoarthritis.The second two-year study was designed to evaluate whether the supplements could reduce the loss of joint cartilage in people with knee osteoarthritis. Chondroitin Sulfate: Benefits, Downsides, Dosage, and MoreChondroitin sulfate is a popular supplement that people often use to help manage joint pain.Though it’s naturally produced in the body, some people choose to take it as a supplement for its potential joint-building properties. Many of these people take it for osteoarthritis (OA).
  
  This article explains everything you need to know about chondroitin sulfate, including its benefits, recommended dosage, and some potential downsides. We use the terms “chondroitin sulfate” and “chondroitin” interchangeably throughout this article. Chondroitin sulfate is a compound present naturally in the body as an essential part of hyaline cartilage, a tissue that cushions your joints.
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